To examine connectivity ranging from dieting and coronary attack, we put Cox proportional problems designs stratified of the age (mo) and you may go after-right up years so you can imagine RRs and you may 95% CIs. Players was indeed put into quintiles out-of cumulative average consumption regarding magnesium, potassium, and calcium to reduce the within-people variation and greatest represent much time-label consumption ( 18). A combined nutrient diet get from magnesium, potassium, and you will Niche singles dating calcium supplements had been computed from the assigning what to for each quintile and you may summing the situations. Users on lowest quintile (quintile step 1) out of magnesium, potassium, otherwise calcium supplements consumption received 1 section for each mineral, members in the next quintile (quintile 2) obtained dos affairs, an such like. Cumulative averages was indeed determined by using the latest imply of the many claimed FFQ intakes around the beginning of for each and every 2-y realize-right up period. New cumulative average consumption was applied so you can anticipate stroke incidence off the full time of your last returned questionnaire before the next realize-right up course.
Multivariate designs was indeed modified to possess years (mo) and you may diary day (2-y go out durations) and you can included consumption of complete times (kcal), alcoholic drinks (g/d), tobacco cigarette, Bmi, physical working out, adult history of early myocardial infarction, postmenopausal hormones procedures explore, thiazide use, aspirin play with, multi vitamin use, and you may history of diabetes, blood circulation pressure, and you will hypercholesterolemia on standard. To check getting a good linear pattern, we assigned for each and every quintile the latest average value and modeled that it changeable as a continuous varying. We checked out the potential departure regarding linearity by using a likelihood proportion shot for testing out of an unit toward linear title that have an unit like the linear identity as well as limited cubic spline changes ( 19). I and held analyses you to definitely integrated the 3 nutritional elements on top of that. Magnesium and you can potassium consumption have been extremely correlated (r = 0.79 regarding the NHS We; r = 0.73 regarding NHS II), and you can correlations ranging from calcium supplements and you will potassium intakes (roentgen = 0.forty two from the NHS We; r = 0.41 in the NHS II), while ranging from calcium and you will magnesium intakes (r = 0.54 from the NHS I; roentgen = 0.56 throughout the NHS II) was indeed modest. The fresh new Q test was used to check on to your heterogeneity anywhere between the new NHS We and you will NHS II. RRs (±SEs) for every quintile away from for each cohort was in fact pooled inside fixed-outcomes habits so you’re able to calculate summary rates ( 20). Also, the newest updated meta-research adopted important habit ( 20) out of testing to own heterogeneity making use of the Q test and using repaired consequences model to create realization quotes whenever zero ranging from-degree heterogeneity is actually obvious; or even a haphazard-consequences design was utilized.
To examine the potential effect modification of the association between dietary minerals and stroke risk by age, hypertension, and diabetes, we stratified our multivariate model on age (<60 compared with ?60 y), hypertension (yes compared with no), and diabetes (yes compared with no) and separately tested the significance of an interaction by using a likelihood ratio test for the comparison of the model with interaction terms to the model with only main effects. All P values were 2-sided, and analyses were conducted with SAS 9.2 software (SAS Institute Inc.).
While in the 29 y out of realize-up out of 1980 because of 2010 on the NHS I and twenty-two y regarding go after-upwards out-of 1989 by way of 2011 in the NHS II, all in all, 3780 event coronary attack instances had been determined. Of them cases, 3237 event shots was indeed noted about NHS We (in addition to 1664 ischemic, 544 hemorrhagic, and you can 1029 unspecified shots), and you can 543 event shots were noted in the NHS II (also 186 ischemic, 92 hemorrhagic, and 265 unspecified shots). Age-standardized features out of studies professionals during the midpoint while in the follow-right up when you look at the 1994 towards the NHS We and in 1995 getting the newest NHS II are shown inside Desk step 1. Females that have high nutrient intake was more likely to play with aspirin, multivitamins, and postmenopausal hormonal procedures, a great deal more myself effective, less inclined to getting most recent cigarette smokers than simply were females with lower mineral consumption. Studies for ladies throughout the NHS I and you will NHS II was in fact shared since the i failed to observe a serious ranging from-study heterogeneity (Q-fact P > 0.05).